Lake Catchment Interaction Analysis by Using Remote Sensing and GIS Techniques – the case study of Kolleru Lake, South India

Wetlands belong to the most productive ecosystem on Earth. They provide many essential services to humans. They play an important role and possess ecosystem services, for example, in biodiversity conservation, for the hydrologic cycle, to buffer regional climate change, and for human health. Among the different types of wetlands, lakes (lacustrine wetlands) play a crucial role in maintaining global and regional water balances, natural and socio-economic resources, and habitats. Over the last decades, the lakes have gone through enormous changes derived from both natural processes and anthropogenic activities. Particularly, freshwater lakes are endangered through point and non-point pollutions, and such impacts are coming from agricultural runoff and industrial pollution, domestic waste, through municipal sewage, which may deteriorate the water quality and their ecological integrity. The Kolleru Lake wetland ecosystem in South India has been taken here as a case study, based on a comprehensive data analysis and modeling of Spatio-temporal variability of the pollutant loads, to achieve a better understanding of the man-environmental problems of the lake and its surrounding catchment. This is a necessary requirement for both better management of the agricultural, industrial, and water resources in the whole area and better lake protection and conservation. Kolleru Lake is the largest freshwater lake in India. It is a huge natural flood balancing reservoir and also a wildlife sanctuary. In 2002, the Ramsar Convention recognized the lake as a wetland of international importance. The lake is predominately fed by rivers. Among them, Budameru and Tammileru rivers are contributing to the lake influx substantially, plus supported by 68 minor irrigation (drainage) canals. The Kolleru Lake covers a total area of more than 90,100 hectares and holding approximately 1,350 cubic miles of freshwater. Additionally, Kolleru Lake provides drinking water to the inhabitants of the surrounded villages. The lake area up to 3' ft contour is consistent with water, while the 5' ft contour level of the Kolleru Lake belongs to the wildlife sanctuary. Further, it is mostly occupied by aquacultures followed by paddy cultivation, weed infests, and marshy land. There are many small scales to large scale industries growing steadily in order to support successful aquaculture. Before the 1970s, the lake area up to 5' ft contour was not occupied by any type of economic activity; however, the lake is saturated with water during the rainy season, and it remains dry during summer. Furthermore, it was completely free from contamination by aquaculture and agricultural activities before the 1970s. After the 1970s, the State Government had distributed the Kolleru Lake up to 5'ft contour area the poor people, migrant workers, and local inhabitants in the promise of whenever the government again needs the lake area, and they can take it back by paying compensation to them. Then farmers have started paddy cultivation in and around the lake. All bed villages in the lake region are frequently severely affected by massive flooding in connection with the submersion of paddy fields. Despite the fact that the state Government had encouraged the farmers to convert the paddy fields into fishponds by providing loans in order to overcome the floods. However, the maximum of lake area up to wildlife sanctuary is practiced by the aquaculture in the 1990s. Since 1970 until the current situation, the lake has been facing some severe environmental threats, such as degraded water quality, deteriorated aqua species and birds, and habitat losses, induced by human activities and accelerated by climate change. A major cause of the environmental problems was identified within the lake by the construction of fishponds resulted in pollution by using pesticides and waste food (exposed to bacterial diseases and infection) to enrich the fish growth. As a result, it causes biological magnification diseases, fertility, and respiratory problems to the animals, birds, and humans who live near to the lake. Thereby the ecosystem will become an inhospitable environment for those aqua species and birds. The fish ponds occupied approximately 42% of the lake area while aquaculture had encroached another 8.5%, together covering 50% of the lake region. If the human-induced debasement of the lake will continue, the lake will no longer cease to exist, and the wildlife species soon will disappear. Apart from the aquaculture tradition, the Kolleru Lake catchment is known for its intensive paddy cultivation. However, the massive application of pesticides and chemical fertilizers to agricultural lands across the catchment area is one reason for the eutrophication in Kolleru Lake. In addition to the several factors that influence the lake ecosystem, industrial pollution causes deteriorating water quality and makes them unfit for drinking water for the inhabitants of the villages around the Kolleru Lake. Both point and non-point sources issued threatens to the lake area becomes more sensitive by anthropogenic activities. The main focus of the present research was to analyze the problems related to the lake catchment and give recommendations to the government about the insight view of the land use cover and enlighten the public perception towards the lake degradation. However, sedimentation in a lake is a natural consequence of the inflow of respected tributaries, rivers, and streams. In addition to the natural influence, man-made activities like land use and others are also responsible for erosion in the catchment and the sediment transport and accumulation of the sediments in both the lower sections of the catchment and the lake basin itself, as discussed in the first research objective. Extensive use of land and the indiscriminate rise of embankments for the construction of fishponds as well as agricultural functions has resulted in widespread soil erosion in the catchment and sedimentation over the deltaic part of the Kolleru Lake catchment. In addition, the perennial rivers of Krishna and Godavari drift down to the lake about 68,000 tons/yr of sediments that coming from the whole catchments after passage from the river banks and river beds. The objective of this part was to analyze both the average annual soil loss rate and its change from the catchment and the sediment yields by using the RUSLE model both for the terrestrial part and the semi-aquatic deltaic part of the Kolleru Lake catchment for the years 1972 and 2012. The results indicated that the average annual soil loss was estimated with 13.6 t/ha/yr, classifying the Kolleru Lake Basin under a very high erosion rate category. Whereas, the average annual sediment yield was determined with 7.61 t/ha/yr. The resultant difference of the sediment balance is temporally interbedded within the terrestrial sites and within the river banks and river beds. However, this study has found that tributaries and streamlines of the catchment carry high sediment loads to the lake. This research has proved how intensive agricultural activities in wetland catchments interact with the pollution levels of the lake, causing a deteriorated water quality. Agricultural runoff (runoff from catchment areas dominated by agricultural use) is the main driving factor of accumulated non-point source pollution of the lake water, with side-effects on sediments and silts near the downstream areas of the Kolleru Lake catchment. It primarily caused eutrophication in the lake subsequently that led to proliferating the weeds. However, the second objective of the research was to estimate the tributaries' sub-basin loads and to highlight the diffuse critical sources against the village communities. For this purpose, the Soil and Water Assessment Tool (SWAT) was used to model the diffuse sources in the catchment. The spatial distribution of nitrate-nitrogen (NO3-N) and total phosphorus (TP) emissions were quantified. Some sub-basins contribute more pollutant load to the lake. Alternately, the first and second BMPs (Best Management Practices) level priority areas were identified. Further, suggestions for the implementation of agricultural management practices have been provided for the crucial protection of the lake ecosystem. Consequently, the Kolleru Lake wetland ecosystem is known for its both abundant water availability as well as water scarcity. The river and streams water diverted into the agricultural lands, and still, there is a dire need for groundwater too. When the monsoon rain was weak, and after rainless summer periods, the lake falls more or less dry. Therefore there is a high demand for groundwater, which is continuously increasing. An effective way to analyze groundwater recharge and groundwater availability is a remote sensing and GIS based mapping. The theoretical concepts are involved in this objective is more useful for t further research of the link between surface emission and groundwater contamination. That is why the present research has been investigated as the third objective, the potential groundwater resources in the catchment. A simple mathematical equation was derived from the catchment hydrologic characteristics. The catchment characteristics were analyzed and based on the previous literature sources, and the thematic weight was assigned to evaluate potential groundwater zones. About 13% of the catchment area falls under poor conditions, 38% of the area falls under moderate conditions, 42% of the area falls under good conditions, and about 7% of the area is under excellent condition. These results are a contribution to future groundwater management projects and artificial recharge plans of the Kolleru Lake catchment to maintain sufficient groundwater levels. Due to the still existing lack of observed data of the tributaries, i.e., runoff, sediment, water quality parameters, nutrient load, the used methods are limited and suitable just for an estimation. Sufficient calibration and validation of the results were also limited because the access to the study area and to an onside research institute was not allowed for the Ph.D. candidate, because of its status as a Ph.D. student from Germany. Field investigations on the interaction of pollutant loads with the runoff would be advantageous for a better calculation of the pollutant load and its dynamic. Because of the limited funding capacity, it is challenging to do a field survey to control every remote sensing and GIS result of this research. That is why, without a few exceptions, this study was conducted dominantly based on remote sensing data and accessible weather and soil data. From the research results emphasized that the Kolleru Lake water level and water quality are highly degraded, respectively polluted with metals, agricultural contaminants, which makes the lake water not advisable for human consumption. The erosion and sedimentation loads are also high, and the priority management practices should be targeted already in the middle catchment region. These results give a general understanding of the pollutant levels in the lake, which should be useful for government management plans.

Guardian of Genetic Messenger-RNA-Binding Proteins

Citation: Anji, A., & Kumari, M. (2016). Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules, 6(1), 18. doi:10.3390/biom6010004RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders, and discuss the role of these proteins in the development of neurological diseases and cancer. We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins

Vertical facial and dental arch dimensional changes in extraction vs. non-extraction orthodontic treatment

OBJECTIVE: To compare the vertical facial and dental arch dimensional changes occurring with extraction and nonextraction orthodontic treatments. STUDY DESIGN: Cross-sectional comparative study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital, Karachi during the period 2003 to 2005. METHODOLOGY: Data were collected using records of patients who visited the study setting during the study period. Pre- and post-treatment lateral cephalographs and study casts of 81 orthodontic patients (41=non-extraction and 40=premolar extractions) were taken. Variables used for evaluating vertical dimension were Frankfort mandibular plane angle (FMA), facial height (N-Me), facial height ratio (N-ANS/ANS-Me), soft tissue facial height (G\u27 to Me\u27), soft tissue facial height ratio (G\u27-Sn\u27/zn\u27-Me\u27), upper first molar to palatal plane and lower first molar to mandibular plane distance, posterior facial height to anterior facial height ratio (PFH/AFH) and Y-axis. Intercanine, interpremolar and intermolar widths and arch depths were also measured. To evaluate the pre-treatment and posttreatment comparison within each group, paired t-tests were used. For pre- and posttreatment comparisons between the extraction and non-extraction groups, independent sample t-tests were used. RESULTS: The mean age was 15.8+/-1.5 years for non-extraction and 15.4+/-1.2 years for the extraction group. There was no significant difference in the vertical dimensional changes between extraction and non-extraction treatments as it increased in both groups. When comparing posttreatment arch dimensions, there was an increase in the maxillary intermolar width in the non-extraction group while the intermolar widths and arch depths decreased in the extraction group in both arches. CONCLUSION: Vertical dimensional changes showed no significant difference between extraction and non-extraction groups. Intermolar widths and arch depths decreased in both arches in the extraction group while the maxillary intermolar width increased in the non-extraction group

Some New Mathematical Tools in Cryptology

In this paper some new mathematical technique used in the design and analysis of cipher systems have been reviewed. Firstly, some modern cryptosystems like stream ciphers, permutation-based systems and public key encryption systems are described and the mathematical tools used in their design have been outlined. Special emphasis has been laid on the problems related to application of computational complexity to cryptosystems. Recent work on the design of the systems based on a combined encryption and coding for error correction has also been reviewed. Some recent system-oriented techniques of cryptanalysis have been discussed. It has been brought out that with the increase in the complexity of the cryptosystems it is necessary to apply some statistical and classification techniques for the purpose of identifying a cryptosystem as also for classification of the total key set into smaller classes. Finally, some very recent work on the application of artificial intelligence technique in cryptography and cryptanalysis has been mentioned

Pseudo broad ligament fibroid mimicking ovarian malignancy: a case report

Fibroids are smooth muscle benign tumors. They arise most commonly from the uterus but may also rise from extra uterine sites like broad ligament. Uterine fibroids are the most common myomas, while uterine cervix and intraligamentary fibroids are statistically less frequent. This case report of Pseudo broad ligament fibroid with extensive cystic degeneration is presented for its rarity and diagnostic challenges as they mimic pelvic adenexal tumors. Following is the case report of a 40 year old, P4L4, postmenopausal female admitted in the department due to a diagnosed solid lesion in the left adnexa. Patient was asymptomatic 3 months back when she noted gradual swelling and distention over the abdomen. On abdomen examination, a generalized mass was palpable with minimal ascites. On ultrasonography, a large heterogenous mass measuring 200X215 mm seen in pelvic region, arising from left adnexa and extending towards abdomen. During laparotomy, left sided fibroid was removed and sent for frozen section analysis. Histopathological reports revealed spindle cells arranged in fascicles and interlacing bundle with focal areas of myxoid degeneration. Huge pseudo-broad ligament leiomyoma with cystic degeneration may present diagnostic difficulties in differentiating ovarian malignancies even on ultrasound and MRI. This differential diagnosis must be considered prior to surgical management.

SUMO Sites Prediction in Human Transcription Factors Involved in Hypoxia induced Cardiac Illnesses

Protein SUMOylation is a reversible and well knownpost-translational modificationprocess of the cells. It may change a protein's cellular location, interactions, and possible structural shape before it develops to carry out its basic functions.Also, it decides the binding of transcription factors and DNA binding proteins tochromatin in addition to various cis and trans regulatory factors. Alterations in protein SUMOylation have been linked with a variety of disorders and developmental anomalies.Tentative approaches to identify SUMO binding sites are challenging due todynamic nature of the SUMOylation processand various critical lab experimentswhich are involved very high cost.Therefore, the computational methodologies may guide the experimental identification of SUMOylation sites and provide insights for improving comprehensionofSUMOylation mechanism in the cells.In this study, we identify the SUMO binding sites in transcription factors that are actively involved and have crucial roles in cardiac development andpathophysiology of the heart.A list of important transcription factors was preparedfrom thehuman transcription factor database.The GPS-SUMO, SUMO plot, and JASSA web serverswere used for the prediction of SUMO binding sites in cardiac transcription factors.We identified the SUMOylation of several novel, previously uncharacterized SUMO targetsthat are actively involved in thecardiovascular system.Thus, the present study may help to uncoverthe significance ofSUMO modificationin cardiac development and illnesses which creates a fresh avenue for future studies ontarget-specific SUMOylation for identification of novel therapeutic targets andmanagement strategies forhypoxia-induced cardiovascular disorders

Studies on antitussive effect of Tectona grandis roots using a cough model induced by sulfur dioxide gas in guinea pigs.

Objectives: Anti-tussive drugs are among the most widely used medications world wide; however no new class of drugs has been introduced into the market by keeping this point in mind. This attempt is made by testing a root of a well known timber tree Tectona grandis. Materials and methods: Here in, we have analyzed the polar compounds of Tectona grandis roots using chemical and biological methods. In this study, in vivo antitussive activity of root extracts (methanol and water) of Tectona grandis Linn. f. (Verbenaceae) was evaluated using a cough model induced by sulfur dioxide gas in rats. Results and Discussion: Treatment with aqueous extract and methanol extract at 500 mg/kg p.o. dose level showed more anti-tussive effect as compared with the dose level of 250mg/kg p.o. Differences between means were assessed by one way analysis of variance (ANOVA),followed by Dunnett’s test using sigma stat software. Both the extracts (methanol and water) significantly (P<0.05) suppressed the asthmas at the dose level of 500mg/kg.Phytochemical tests showed that methanol and water extracts tested positive for carbohydrates, reducing sugars, alkaloids, glycosides, flavonoids, sterols and saponins. Conclusion: This study provides a scientific basis on ethno medical uses of this plant. Further exploration in drug development of anti-tussives from Tectona grandis can focus on the purity activity relationships (PAR studies).

Epidemiological and clinical profile of various plant poisons in a tertiary care center in South Tamilnadu, India

Background: Plant poisoning is a common scenario in a toxicology unit . Some of the plants contain active components used as medicines. However, some of the plant constituents are poisonous with wide variety of clinical manifestations. Authors aimed to study the pattern of various types of plant poisons and clinical presentations and complications of various plant poisons admitted in our toxicological unit.Methods: A total of 87 patients admitted with history of plant poison ingestion, in toxicological unit of Tirunelveli medical college were studied . It was a retrospective observational study and was done over a period of one year.Results:  Out of 87 cases studied, 92%were due to consumption with suicidal intention. Plant poisoning ranks second only to pesticide poisoning . among the plant poisons encountered 66.6% were due to Oleander poison, followed by Datura (8%) and Glory lily(5.7%). Common parts of plant consumed by patients include seeds and plant oils . Vomiting and abdominal pain were the commonest presentations. Encephalopathy, dyselectrolytemia and arrhythmias were the notable complications in our study.Conclusions: Early admission and prompt first aid and monitoring at tertiary care center are key to the reduced mortality. The study throws light on various manifestations, toxic parts and complications of plant poisons